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K-TMZ
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
K-TMZ图片
CAS NO:2269482-26-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Cas No.2269482-26-8
Canonical SMILESCN(N=N1)C(N2C1=C(C(C)=O)N=C2)=O
分子式C7H7N5O2
分子量193.2
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM). K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.