CB-1954 (CB 1954) 是一种抗肿瘤前药，对 Walker 256 大鼠肿瘤系具有高度选择性。 CB-1954 经酶促活化生成双功能试剂，可形成 DNA-DNA 链间交联。大鼠细胞中的 CB-1954 涉及通过酶 NAD(P)H:醌氧化还原酶 1 (NQO1) 将其 4-硝基还原为 4-羟胺。
| Cas No. | 21919-05-1 |
| 别名 | 5-(1-氮杂环丙基)-2,4-二硝基苯甲酰胺,CB 1954 |
| Canonical SMILES | O=C(N)C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C(N2CC2)=C1 |
| 分子式 | C9H8N4O5 |
| 分子量 | 252.2 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent. |
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