SL 01 是吉西他滨的口服活性前药，旨在提高口服生物利用度。
| Cas No. | 26049-94-5 |
| 别名 | N-苯氧基碳-L-苯丙氨酰甲基氯酮,SL-01 |
| Canonical SMILES | O=C(CCl)[C@@H](NC(OCC1=CC=CC=C1)=O)CC2=CC=CC=C2 |
| 分子式 | C18H18ClNO3 |
| 分子量 | 331.8 |
| 溶解度 | DMF: 33 mg/ml,DMSO: 33 mg/ml,DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth. |
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