| CAS NO: | 303126-97-8 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 303126-97-8 |
| 化学名 | 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide |
| Canonical SMILES | ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O |
| 分子式 | C16H10ClF6NO2 |
| 分子量 | 397.7 |
| 溶解度 | ≤30mg/ml in ethanol;15mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SR 0987 is an agonist of RORγt with EC50 value of ~800 nM for inducing reporter gene expression [1]. RORγt (retinoic acid receptor-related orphan receptor-γt), the T cell-specific isoform of RORγ, is the key lineage-defining transcription factor to initiate the differentiation program of TH17 and Tc17 cells, cells that have demonstrated anti-tumor efficacy [1]. SR 0987 is a RORγt agonist. In murine EL4 T lymphocytes, SR 0987 increased expression of IL17 while repressing the expression of the checkpoint receptor PD-1, suggesting that SR 0987 enhanced protective immunity by regulating expression of IL17 and PD-1 while maintaining the cytotoxic ability of these cells. In both the 5xRORE and IL17 promoter transfected cells, SR0987 concentration dependently induced reporter gene expression with an EC50 of ~800 nM. SR0987 also concentration dependently increased interaction of RORγt with the SRC1-3 NR box peptide [1]. Reference: |
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