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Pioglitazone D4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pioglitazone D4图片
CAS NO:1134163-29-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
PioglitazoneD4(U72107D4)是一种Pioglitazone氘代物。Pioglitazone(U72107)是一种有效的选择性PPARγ激动剂,高亲和力结合到PPARγ配体结合域,作用于人和鼠PPARγ,EC50分别为0.93和0.99μM。
Cas No.1134163-29-3
别名匹格列酮-D4,U 72107-d4
Canonical SMILESO=C(N1)SC(CC2=C([2H])C([2H])=C(OCCC3=NC=C(CC)C=C3)C([2H])=C2[2H])C1=O
分子式C19H16D4N2O3S
分子量360.46
溶解度DMF: 2.5 mg/ml,DMSO: 2.5 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pioglitazone D4 (U 72107 D4) is a deuterium labeled Pioglitazone. Pioglitazone (U 72107) is a potent and selective PPARγ agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively[1].

[1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose leve