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A6770
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A6770图片
CAS NO:1331754-16-5
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
A6770 是一种具有口服活性的强效 1-磷酸鞘氨醇 (S1P) 裂解酶 (S1PL) 抑制剂。
Cas No.1331754-16-5
Canonical SMILESOCC1=CN=C(C(C)=O)N1
分子式C6H8N2O2
分子量140.1
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50=<0.01 µM), an effect that is reduced in the presence of vitamin B6(EC50=<100 µM).

1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)