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Amiodarone-d4(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amiodarone-d4(hydrochloride)图片
CAS NO:1216715-80-8
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
胺碘酮-d4(盐酸盐)是盐酸胺碘酮的氘标记。
Cas No.1216715-80-8
别名盐酸胺碘酮-d4
Canonical SMILESCCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1Cl
分子式C25H25D4I2NO3.HCl
分子量685.8
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amiodarone-d4is intended for use as an internal standard for the quantification of amiodarone by GC- or LC-MS. Amiodarone is a class III antiarrhythmic agent, in that it prolongs both cardiac action potential and refractoriness by blocking potassium currents.1It inhibits the voltage-gated potassium channel hERG, also known as KCNH2, with an IC50value of 1 µM.2In addition, amiodarone binds with high affinity to the sigma-1 opioid receptor, 3-β-hydroxysteroid δ8δ7isomerase, and C-8 sterol isomerase (Kis = 1, 25, and 62 nM, respectively) and inhibits human thyroid hormone receptors α and β (IC50s = 0.6 and 0.65 µM, respectively).3,4It also inhibits the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4in vitroat low micromolar concentrations.5

1.Campbell, T.J., and Williams, K.M.Therapeutic drug monitoring: Antiarrhythmic drugsBr. J. Clin. Pharmacol.52307-319(1998) 2.Sinha, N., and Sen, S.Predicting hERG activities of compounds from their 3D structures: Development and evaluation of a global descriptors based QSAR modelEur. J. Med. Chem.46(2)618-630(2011) 3.Laggner, C., Schieferer, C., Fiechtner, B., et al.Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screeningJ. Med Chem.48(15)4754-4764(2005) 4.Carlsson, B., Singh, B.N., Temciuc, M., et al.Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodaroneJournal of Medicinal Chemistry45(3)623-630(2002) 5.Polasek, T.M., Elliott, D.J., Lewis, B.C., et al.Mechanism-based inactivation of human cytochrome P4502C8 by drugs in vitroJ. Pharmacol. Exp. Ther.311(3)996-1007(2004)