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Cholic Acid-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cholic Acid-d4图片
CAS NO:116380-66-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
胆酸-d4 是氘标记的胆酸。
Cas No.116380-66-6
别名胆酸 d4
Canonical SMILESO[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])C1([2H])[2H]
分子式C24H36D4O5
分子量412.6
溶解度DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cholic acid-d4is intended for use as an internal standard for the quantification of cholic acid by GC- or LC-MS. Cholic acid is a primary bile acid.1It is formed from cholesterolviaa multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. Cholic acid is conjugated to glycine or taurine by bile acid-CoA:amino acid N-acyltransferase (BAAT) to produce glycocholic acid and taurocholic acid , respectively, in the liver, and is transformed into the secondary bile acid deoxycholic acid by intestinal microbiota.1,2,3It inducesC. difficilecolony formation in an agar dilution assay when used at a concentration of 0.1% w/v.4Dietary administration of cholic acid (0.4% w/w) increases serum cholesterol levels, biliary phospholipid secretion, and fecal DCA levels in rats.5

1.šarenac, T.M., and Mikov, M.Bile acid synthesis: From nature to the chemical modification and synthesis and their applications as drugs and nutrientsFront. Pharmacol.9939(2018) 2.Hunt, M.C., Siponen, M.I., and Alexson, S.E.H.The emerging role of acyl-CoA thioesterases and acyltransferases in regulating peroxisomal lipid metabolismBiochim. Biophys. Acta1822(9)1397-1410(2012) 3.Staley, C., Weingarden, A.R., Khoruts, A., et al.Interaction of gut microbiota with bile acid metabolism and its influence on disease statesAppl. Microbiol. Biotechnol.101(1)47-64(2017) 4.Sorg, J.A., and Sonenshein, A.L.Bile salts and glycine as cogerminants for Clostridium difficile sporesJ. Bacteriol.190(7)2505-2512(2008) 5.Uchida, K., Nomura, Y., and Takeuchi, N.Effects of cholic acid, chenodeoxycholic acid, and their related bile acids on cholesterol, phospholipid, and bile acid levels in serum, liver, bile, and feces of ratsJ. Biochem.87(1)187-194(1980)