α-Hydroxyglutaric Acid (2-Hydroxyglutarate) 是一种 α-羟基酸形式的戊二酸。 α-Hydroxyglutaric Acid 是多种 α-酮戊二酸依赖性双加氧酶的竞争性抑制剂，包括组蛋白去甲基化酶和 5-甲基胞嘧啶 (5mC) 羟化酶的 TET 家族。
| Cas No. | 2889-31-8 |
| 别名 | 2-Hydroxyglutarate; 2-Hydroxyglutaric acid; 2-Hydroxypentanedioic acid |
| 化学名 | 2-hydroxy-pentanedioic acid |
| Canonical SMILES | OC(C(CCC(O)=O)O)=O |
| 分子式 | C5H8O5 |
| 分子量 | 148.1 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases. |
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