SW155246 是一种 DNA 甲基转移酶 (DNMT1) 选择性抑制剂，对 hDNMT1 和 mDNMT3A 的 IC50 分别为 1.2 和 38 μM。 SW155246可用于癌症等疾病的研究。
| Cas No. | 420092-79-1 |
| 化学名 | 4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide |
| Canonical SMILES | ClC1=CC=C(S(NC2=CC=C(O)C3=C2C=CC=C3)(=O)=O)C=C1[N+]([O-])=O |
| 分子式 | C16H11ClN2O5S |
| 分子量 | 378.8 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.16 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SW155246 is an inhibitor of DNA methyltransferase 1 (DNMT1; IC50 = 1.2 μM). It is selective for human DNMT1 over murine DNMT3 (IC50 = 38 μM). SW155246 inhibits HeLa and A549 tumor cell growth in a redox-independent manner (IC50s = 8-20 μM). It also inhibits genomic methylation in HeLa cells when used at concentrations ranging from 10 to 18.6 μM. |
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