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SIRT-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SIRT-IN-1图片
CAS NO:1431411-60-7
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
SIRT-IN-1是SIRT1/2/3的有效抑制剂，其IC50值分别为15，10，33μM。
Cas No.1431411-60-7
Canonical SMILESNC(C1=CC2=NC=NC(N3CCC(CCNC(C(C)(C)C)=O)CC3)=C2S1)=O
分子式C19H27N5O2S
分子量389.52
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SIRT-IN-1 is a potent inhibitor of SIRT1/2/3, with IC50s of 15, 10, 33 μM, respectively.

SIRT-IN-1 (compound 28) is one of the most potent truncated pan SIRT1/ 2/3 inhibitor, the IC50 values are 0.015, 0.010, 0.033 μM, respectively. SIRT-IN-1 (SIRT1/2/3 pan inhibitor) binds identically in the catalytic active site (RMS=0.29 ?), occupying the nicotinamide C-pocket and acetyl lysine substrate channel[1].

[1]. Disch JS, et al. Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.