CAS NO: | 107438-79-9 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Cas No. | 107438-79-9 |
别名 | 银杏内酯J |
Canonical SMILES | O[C@@]1([C@@H]2C)C3(O[C@@](OC4=O)([H])C5([C@H]4O)[C@H](C(C)(C)C)[C@@H](O)[C@@]6([H])OC3=O)[C@@]56C[C@]1([H])OC2=O |
分子式 | C20H24O10 |
分子量 | 424.4 |
溶解度 | DMF: 10mg/mL,DMSO: 25mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 10mg/mL |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability[1][2]. Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by serum deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons[1]. [1]. Ahlemeyer B, et al. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 2003 Jun; 36 Suppl 1:S8-14. [2]. Sylvia Pietri, et al. Synthesis and Biological Studies of a New Ginkgolide C Derivative: Evidence That the Cardioprotective Effect of Ginkgolides Is Unrelated to PAF Inhibition. DRUG DEVELOPMENT RESEARCH. 2001.54:191-201. |