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7,8-Dihydroneopterin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
7,8-Dihydroneopterin图片
CAS NO:1218-98-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
7,8-Dihydroneopterin 是一种炎症标志物，可通过增强一氧化氮合酶 (iNOS) 的表达来诱导星形胶质细胞和神经元的细胞凋亡。
Cas No.1218-98-0
别名7,8-二氢-D-新蝶呤
化学名2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone
Canonical SMILESO=C1C2=C(NCC([C@H](O)[C@H](O)CO)=N2)NC(N)=N1
分子式C9H13N5O4
分子量255.2
溶解度0.3 mg/ml in DMF, 1 mg/ml in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

7,8-Dihydroneopterin is a pteridine with antioxidant activities.[1] It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay when used at concentrations ranging from 20 to 100 μM. 7,8-Dihydroneopterin (2-10 μM) inhibits copper ion-induced oxidation of LDL in a cell-free assay and decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL.[2],[3] It inhibits necrosis induced by oxidized LDL (oxLDL) in U937, but not THP-1, cells when used at a concentration of 200 μM.[4]

Reference:
[1]. Oettl, K., Greilberger, J., and Reibnegger, G. Dihydroneopterin as a scavenger of nitrogen centered radicals. Pteridines 11(3), 90-93 (2000).
[2]. Gieseg, S.P., Reibnegger, G., Wachter, H., et al. 7,8 Dihydroneopterin inhibits low density lipoprotein oxidation in vitro. Evidence that this macrophage secreted pteridine is an anti-oxidant. Free Radic. Res. 23(2), 123-136 (1995).
[3]. Gieseg, S.P., and Cato, S. Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin. Redox Rep. 8(2), 113-115 (2003).
[4]. Baird, S.K., Reid, L., Hampton, M.B., et al. OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochim Biophys. Acta. 1745(3), 361-369 (2005).