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Seletracetam
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Seletracetam图片
CAS NO:357336-74-4
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Seletracetam (Ucb 44212) 是一种抗癫痫药 Levetiracetam 的类似物。Seletracetam 是一种用于癫痫研究的小分子 SV2A 调制剂。
Cas No.357336-74-4
别名Ucb 44212
分子式C10H14F2N2O2
分子量232.23
储存条件Store at -20°C, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Seletracetam (Ucb 44212), as an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy[1][2][3].

Seletracetam decreases seizure activity in a number of epilepsy models and binds to the synaptic vesicle protein SV2A[2].Seletracetam decreases synaptic responses in a time-, frequency- and concentration-dependent manner[2].Seletracetam modifies rates of presynaptic release[2].Seletracetam inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[3].

[1]. Pollard JR, et al. Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy. Curr Opin Investig Drugs. 2008 Jan;9(1):101-7.
[2]. Martella G, et al. Seletracetam (ucb 44212) inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro. Epilepsia. 2009 Apr;50(4):702-10.
[3]. Yang X, et al. Seletracetam enhances short term depression in vitro. Epilepsy Res. 2015 Nov;117:17-22.