| CAS NO: | 256955-84-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 256955-84-7 |
| 别名 | Co 134444 |
| 分子式 | C26H40N2O3 |
| 分子量 | 428.61 |
| 溶解度 | DMSO : 100 mg/mL (233.31 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects[1]. In mice, Co 134444 (0.5-10 mg/kg, IP, 15 min; 1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED50 of 3.3 mg/kg after IP administration and 9.8 mg/kg orally. Similarly, protection against maximal electroshock (MES) is observed with an ED50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED50 of 23.6 mg/kg and 25.3 mg/kg, respectively[1]. [1]. Vanover KE, et al. Behavioral characterization of Co 134444 (3alpha-hydroxy-21-(1’-imidazolyl)-3beta-methoxymethyl-5alpha- pregnan-20-one), a novel sedative-hypnotic neuroactive steroid. Psychopharmacology (Berl). 2001;155(3):285-291. |
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