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PEG2000-C-DMG
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PEG2000-C-DMG图片
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议

产品介绍
PEG2000-C-DMG,一种脂质体,可用于制备 Onpattro。Onpattro 是一种肝脏导向的研究性 RNAi 治疗剂,通过靶向甲状腺素运载蛋白 mRNA的3′非翻译区,利用这一过程减少突变型和野生型甲状腺素运载蛋白的产生。
分子式C38H73NO8
分子量2706.38
溶解度DMSO : 100 mg/mL (36.95 mM; Need ultrasonic)
储存条件Store at -20°C, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PEG2000-C-DMG, a lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3′ untranslated region of transthyretin mRNA[1][2].

[1]. Garber K. Alnylam launches era of RNAi drugs. Nat Biotechnol. 2018;36(9):777-778. [2]. Adams D, Gonzalez-Duarte A, O’Riordan WD, et al. Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis. N Engl J Med. 2018;379(1):11-21.