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Pifithrin-α(PFTα)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pifithrin-α(PFTα)图片
CAS NO:63208-82-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)367.3
FormulaC16H18N2OS.HBr
CAS No.63208-82-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 67 mg/mL (182.41 mM)
Water:<1 mg/mL (slightly soluble or insoluble)
Ethanol: 2 mg/mL (6.08 mM)
Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SMILES CodeCC1=CC=C(C(CN2C(SC3=C2CCCC3)=N)=O)C=C1.[H]Br
SynonymsPifithrin-alpha; Pifithrin alpha; PFTalpha; PFTalpha; PFT alpha
实验参考方法
GeneralPifithrin-α (2.2 mg/kg i.p.) treatment completely rescues mice (C57BL and Balb/c) of both strains from 60% killing doses of gamma irradiation (8 Gy for C57BL and 6 Gy for Balb/c). Pifithrin-α-injected mice lost less weight than irradiated mice that are not pretreated with the Pifithrin-α. Pifithrin-α (2.2 mg/kg) abrogates p53-dependent regulation of DNA replication after whole-body gamma irradiation in mice.
Animal modelC57BL and Balb/c mice
FormulationDissolved in Saline
Dosages2.2 mg/kg
Administrationi.p
References[1] Komarov PG, et al. Science, 1999, 285(5434), 1733-1737.
生物活性

IS upregulates α-SMA protein through p53 and ROS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.

IS induces activated p53 expression, which is involved in suppression of serum-induced proliferation of HK-2 cells caused by IS. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.

IS-induced HK-2 cell senescence is inhibited by PFTα. Am J Physiol Cell Physiol. 2010 Nov;299(5):C1110-7.