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Ursodeoxycholic Acid(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ursodeoxycholic Acid(sodium salt)图片
CAS NO:2898-95-5
包装与价格:
包装价格(元)
250mg电议
500mg电议
1g电议
5g电议

产品介绍
熊去氧胆酸 (Ursodeoxycholate) 钠是肠道细菌转化 (cheno) 脱氧胆酸后产生的次级胆汁酸,是肠道屏障完整性的关键调节剂,对脂质代谢至关重要。
Cas No.2898-95-5
别名熊去氧胆酸钠盐; Ursodeoxycholate sodium; Ursodiol sodium; UCDA sodium
Canonical SMILES[O-]C(CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C)=O.[Na+]
分子式C24H39O4•Na
分子量414.6
溶解度DMF: 5 mg/ml,DMSO: 10 mg/ml,Ethanol: 15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid . UDCA is also a metabolite of lithocholic acid in human liver microsomes. It inhibits taurocholic acid uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM. UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid or ethanol in primary rat hepatocytes. Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.