您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > CP-060
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
CP-060
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CP-060图片
CAS NO:180090-15-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
CP-?060 是一种 Ca2+ 拮抗剂，能够抑制 Ca2+ 过载，具有抗氧化、保护心脏的作用。
Cas No.180090-15-7
Canonical SMILESO=C1N(CCCN(CCOC2=CC=C(OCO3)C3=C2)C)C(C4=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C4)SC1
分子式C30H42N2O5S
分子量542.73
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CP-?060 is a potent Ca2+ antagonist, inhibits Ca2+ overload and possesses antioxidant and cardioprotective activities.

CP-?060 (0.5, 5 μM) inhibits rabbit LDL oxidation induced by soybean lipoxygenase by 12.9% and 3.0%, respectively[1].

CP-?060 (100 mg/kg, i.v.) increases the coronary blood flow by 96% in anesthetized dogs[2].

[1]. Kato T, et al. Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 1. 2-(3, 5-di-tert-butyl-4-hydroxyphenyl)-3-(aminopropyl)thiazolidinones. J Med Chem. 1998 Oct 22;41(22):4309-16. [2]. Kato T, et al. Novel calcium antagonists with both calcium overload inhibition and antioxidant activity. 2. Structure-activity relationships of thiazolidinone derivatives. J Med Chem. 1999 Aug 12;42(16):3134-46.