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ORM-10962
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ORM-10962图片
CAS NO:763926-98-3
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ORM-10962 是有效的、高度选择性的钠钙交换器 (NCX) 抑制剂，对正向反向模式抑制的 IC50 值分别为 67 nM 和 55 nM。
Cas No.763926-98-3
Canonical SMILESO=C(NC1=CC=C(OC2=CC=C3C(CCC(C4=CC=CC=C4)O3)=C2)N=C1)CN5CCC(O)CC5
分子式C27H29N3O4
分子量459.54
溶解度DMSO: 250 mg/mL (544.02 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively[1][2]. NCX[1][2].

[1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041. [2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.