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PF 05089771
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 05089771图片
CAS NO:1235403-62-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
25mg电议
100mg电议

产品介绍
PF 05089771是出自专利WO/2010/079443 A1中的Nav1.7离子通道阻断剂,IC50值8.6nM。
Cas No.1235403-62-9
Canonical SMILESO=S(C1=CC(Cl)=C(OC2=CC=C(Cl)C=C2C3=CNN=C3N)C=C1F)(NC4=CSC=N4)=O
分子式C18H12Cl2FN5O3S2
分子量500.35
溶解度DMSO: ≥ 34 mg/mL (67.95 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF 05089771 is a Nav1.7 channel blocker extracted from patent WO/2010/079443 A1, compound example 788, has an IC50 of 8.6 nM.

[1]. Norinder U, et al. QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform. Bioorg Med Chem Lett. 2013 Jan 1;23(1):261-3. [2]. BEAUDOIN, et al. SULFONAMIDE DERIVATIVES. Patent WO/2010/079443 A1.