Pozanicline

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Pozanicline

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

161417-03-4

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

Pozanicline (ABT-089) 是一种新型的胆碱能药物，是 α4β2* nAChRs 部分激动剂，显示对 α6β2* 和 α4α5β2 nAChR 亚型的高选择性。Pozanicline 与 [3H] cytisine位点的结合亲和力 (Ki; rat) 为 16.7 nM。Pozanicline 逆转尼古丁戒断诱导的认知缺陷，可能是尼古丁成瘾的新治疗策略的有效组成部分。

Cas No.	161417-03-4
别名	ABT-089
Canonical SMILES	CC1=C(OC[C@H]2NCCC2)C=CC=N1
分子式	C₁₁H₁₆N₂O
分子量	192.26
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.Pozanicline reverses nicotine withdrawal-induced cognitive deficits, may be an effective component of novel therapeutic strategies for nicotine addiction[1]. Ki: 16 nM (α4β2* nAChR)[1] [1]. Sullivan JP, et al. ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46. [2]. Yildirim E, et al. ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice. Behav Pharmacol. 2015 Apr;26(3):241-8.