| CAS NO: | 392-12-1 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1 g | 电议 |
| Cas No. | 392-12-1 |
| 别名 | 吲哚-3-丙酮酸 |
| 化学名 | α-oxo-1H-indole-3-propanoic acid |
| Canonical SMILES | O=C(C(O)=O)CC1=CNC2=CC=CC=C21 |
| 分子式 | C11H9NO3 |
| 分子量 | 203.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid , in plants.[1][2][3] Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.[1] It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.4Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression ofIl1b,Ifng,Tnfa, andIl12bin a mouse model of T cell-mediated colitis.[1] It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.[2] It also reverses the anxiogenic effect of caffeine and 3-hydroxy kynurenine, but not pentylenetetrazole or phenylethylamine, in the elevated plus maze in mice. Reference: |
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