| Cas No. | 1262036-49-6 |
| 别名 | N-[3-[(4AS,7AS)-2-氨基-5,7-二氢-4H-呋喃并[3,4-D][1,3]噻嗪-7A(4AH)-基]-4-氟苯基]-5-氟-2-吡啶甲酰胺盐酸盐 |
| Canonical SMILES | [H][C@@]12COC[C@]1(C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F)N=C(SC2)N.Cl |
| 分子式 | C18H16F2N4O2S.HCl |
| 分子量 | 426.87 |
| 溶解度 | DMSO|42.69|100| |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model. |
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