| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
Cell lines | M-1 cells |
Preparation method | The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 ℃ for several months. |
Reacting condition | 1 nM ~ 1 μM; 24 hrs |
Applications | In M-1 cells, Medroxyprogesterone Acetate at the dose of 1 μM increased α-epithelial Na channel (α-ENaC) and serum and glucocorticoid-regulated kinase 1 (sgk1) expression. Medroxyprogesterone Acetate dose-dependently increased α-ENaC expression with the earliest effect seen at 10 nM. In Medroxyprogesterone Acetate-treated M-1 cells, α-ENaC-driven luciferase activity could not be inhibited by Org31710, which indicated that Medroxyprogesterone Acetate regulated α-ENaC in a progesterone receptor (PR)-independent manner. |
Animal models | Rats |
Dosage form | 14 and 21 mg/2 mL; given via osmotic pumps |
Applications | In aged ovariectomized rats, Medroxyprogesterone acetate impaired delayed memory retention on the water radial-arm maze, and exacerbated overnight forgetting on the Morris maze. Medroxyprogesterone acetate significantly decreased the level of glutamic acid decarboxylase (GAD) in the hippocampus, and increased GAD level in the entorhinal cortex. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
| 产品描述 | Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors[1]。 References: |
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