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Taltirelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Taltirelin图片
CAS NO:103300-74-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Taltirelin (TA0910) 是促甲状腺素释放激素受体 (TRH-R) 的超级激动剂,IC50 为 910 nM,EC50 为 36 nM,可刺激细胞溶质 Ca2+ 浓度(Ca2+ 释放)的增加。
Cas No.103300-74-9
别名他替瑞林; TA-0910
化学名(S,Z)-2-hydroxy-N-((S)-1-((S)-2-(hydroxy(imino)methyl)pyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-1-methyl-6-oxo-1,4,5,6-tetrahydropyrimidine-4-carbimidic acid
Canonical SMILESCN(C(O)=N1)C(C[C@@]1([H])/C(O)=N/[C@@](C(N2CCC[C@@]2([H])C(O)=N)=O)([H])CC3=CN=CN3)=O
分子式C17H23N7O5
分子量405.41
溶解度Soluble to 50 mM in sterile water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)[1].

References:
[1]. Thirunarayanan N, et al. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. Front Endocrinol (Lausanne). 2012 Oct 9;3:120.