Fluorobexarotene (compound 20) 是一种有效的维甲酸-X-受体 (RXR) 激动剂,对 RXRα 受体的 Ki 值为 12 nM,EC50 值为 43 nM。 Fluorobexarotene 具有比 Bexarotene 高 75% 的明显 RXR 结合亲和力。
Cas No. | 1190848-23-7 |
化学名 | 2-fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid |
Canonical SMILES | CC1=CC(C(C)(CCC(C)2C)C)=C2C=C1C(C3=CC(F)=C(C(O)=O)C=C3)=C |
分子式 | C24H27FO2 |
分子量 | 366.47 |
溶解度 | <36.65mg/ml in DMSO;<9.16mg/ml in ethanol |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |