LE 135 是一种有效的 RAR 拮抗剂，可选择性地结合 RARα（Ki 为 1.4 μM）和 RARβ（Ki 为 220 nM），并且对 RARβ 具有更高的亲和力。
| Cas No. | 155877-83-1 |
| 化学名 | 4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid |
| Canonical SMILES | OC(C1=CC=C(C=C1)C2=NC3=C(C=C4C(C)(C)CCC(C)(C)C4=C3)N(C)C5=CC=CC=C52)=O |
| 分子式 | C29H30N2O2 |
| 分子量 | 438.56 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 12.5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 1.1 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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