Y 134 是一种选择性和口服活性的雌激素受体 (ER) 调节剂 (SERM)，对 ERα 和 ERβ 表现出有效的拮抗剂活性。 Y 134 对 ERα (Ki\u003d0.09 nM) 的选择性比对 ERβ (Ki\u003d11.31 nM) 的选择性高 121.1 倍。 Y 134 抑制雌激素刺激的 ER 阳性人乳腺癌细胞增殖。
| Cas No. | 849662-80-2 |
| 化学名 | (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(4-isopropylpiperazin-1-yl)phenyl)methanone |
| Canonical SMILES | O=C(C1=C(C(C=C2)=CC=C2O)SC3=CC(O)=CC=C13)C4=CC=C(C=C4)N5CCN(C(C)C)CC5 |
| 分子式 | C28H28N2O3S |
| 分子量 | 472.6 |
| 溶解度 | <47.26mg/ml in DMSO;<47.26mg/ml in ethanol |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
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