| CAS NO: | 1331782-27-4 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1331782-27-4 |
| Canonical SMILES | OC1(CCOCC1)CN(CC2)CCC2COC3=NOC4=CC=CC(OC5COCC5)=C43 |
| 分子式 | C23H32N2O6 |
| 分子量 | 432.5 |
| 溶解度 | Chloroform: 30 mg/ml,DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg. |1. Brodney, M.A., Johnson, D.E., Sawant-Basak, A., et al. Identification of multiple 5•HT4 partial agonist clinical candidates for the treatment of alzheimer's disease. J. Med. Chem. 55(21), 9240-9254 (2012). |
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