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ML-396
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ML-396图片
CAS NO:1630936-95-6
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
ML-396 是 III 组 mGluRs 的正变构调节剂，在钙动员试验中对 mGluR4、mGluR7 和 mGluR8 的 EC50 值分别为 108、146 和 128 nM。
Cas No.1630936-95-6
别名ML396
Canonical SMILESO=C(NC1=CC(Cl)=C(OC2=CC=C(Cl)C=N2)C=C1)C3=CC=CC=N3
分子式C17H11Cl2N3O2
分子量360.2
溶解度Chloroform: slightly soluble,DMSO: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ML-396 is a positive allosteric modulator of group III metabotropic glutamate receptors (mGluRs) with EC50 values of 108, 146, and 128 nM for mGluR4, mGluR7, and mGluR8, respectively, in calcium mobilization assays.1 ML-396 potentiates LSP4-2022-induced reductions in paired-pulse field excitatory post synaptic potential (fEPSP) slopes in mouse hippocampal slices. In vivo, ML-396 (30 mg/kg) restores hippocampal long-term potentiation, improves novel object recognition, contextual fear learning, and social memory, and decreases sleep apneas in the Mecp2-/- mouse model of Rett syndrome.2

|1. Jalan-Sakrikar, N., Field, J.R., Klar, R., et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem. Neurosci. 5(12), 1221-1237 (2014).|2. Gogliotti, R.G., Senter, R.K., Fisher, N.M., et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci. Transl. Med. 9(403), (2017).