| CAS NO: | 1104-22-9 |
| 包装: | 50mg |
| 市场价: | 305元 |
| Cas No. | 1104-22-9 |
| 别名 | 盐酸美克洛嗪; Meclozine dihydrochloride |
| 化学名 | 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride |
| Canonical SMILES | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
| 分子式 | C25H27Cl2N2.2HCl |
| 分子量 | 463.87 |
| 溶解度 | ≥ 48.9mg/mL in DMSO with ultrasonic |
| 储存条件 | Store at 2-8℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Meclizine dihydrochloride is a histamine H1 receptor antagonist and has the potential to treat nausea and motion sickness. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects[1]. Meclizine dihydrochloride is an agonist ligand for mouse CAR (constitutive androstane receptor), and an inverse agonist for human CAR. Meclizine increases mCAR transactivation in a dose-dependent manner, stimulates binding of steroid receptor coactivator 1 to the murine receptor in vitro. In contrast, Meclizine (dihydrochloride) suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR[2]. References: |
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