| CAS NO: | 64-77-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| Cas No. | 64-77-7 |
| 别名 | 甲苯磺丁脲 |
| 化学名 | 1-butyl-3-(4-methylphenyl)sulfonylurea |
| Canonical SMILES | CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C |
| 分子式 | C12H18N2O3S |
| 分子量 | 270.35 |
| 溶解度 | ≥ 10.05mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tolbutamide is a potent inhibitor of cAMP with an IC50 value of 4mM [1]. Tolbutamide has been reported to inhibit both the basal and the cyclic AMP-stimulated protein kinase activites with an IC50 value of 4mM for cyclic AMP-dependent kinase activity. In addition, Tolbutamide has been revealed to inhibit both soluble and membrane-bound protein kinase from canine heart. Moreover, the Tolbutamide inhibition of adipose tissue cyclic AMP- dependent protein kinase is explanation for antilipolytic effects [1]. Besides, Tolbutamide and dbcAMP has been exhibited to increase about four-fold levels of Cx43 mRNA and decrease about 80% the expression of Ki-67 [2]. References: |
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