| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 1g | 电议 |
Histone deacetylase inhibitor
Cell lines | 2 adenoma-derived cell lines (AA/Cl and RG/C2) |
Preparation method | The solubility of this compound in DMSO is limited. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 ℃ for several months. |
Reacting condition | 1 ~ 4 mM; 4 days |
Applications | In RG/C2 cells, Sodium Butyrate at the concentrations of 2 mM and above reduced the attached-cell yield to approximately 50% of the control, and significantly increased the proportion of floating cells. It was demonstrated that the increase in the percentage of floating cells was attributed to the induction of apoptosis and not simply due to increased necrosis. Compared with RG/C2 cells, AA/Cl cells were more sensitive to Sodium Butyrate. |
Animal models | An R6/2 transgenic mouse model of Huntington's disease (HD) |
Dosage form | 100, 200, 400, 600, 1200, 5000 and 10,000 mg/kg; i.p.; q.d. |
Applications | In an R6/2 transgenic mouse model of HD, Sodium Butyrate significantly extended survival in a dose-dependent manner, improved body weight and motor performance, as well as delayed the neuropathological sequelae. Moreover, Sodium Butyrate increased the level of histone and specificity protein-1 acetylation, and protected against 3-nitropropionic acid-induced neurotoxicity. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
| 产品描述 | Sodium butyrate is a short chain fatty acid that has effects at the molecular, cellular, and tissue level. It has long been known as an inhibitor of histone deacetylases (HDACs).[1],[2] In cells, this alters the expression of a select group of genes containing butyrate response elements and may also involve Sp1/Sp3 binding sites.[3] Sodium butyrate also induces growth arrest, differentiation and apoptosis in cancer cells, primarily through its effects on HDAC activity.[4] In addition, it suppresses inflammation, in part by reducing the expression of pro-inflammatory cytokines, including interferon-γ, interleukin (IL)-6, and IL-1β.[5] |
m.cnreagent.com