Metyrapone (Su-4885) 是一种有效且具有口服活性的 11β-羟化酶抑制剂和自噬激活剂，还抑制醛固酮的产生。
| Cas No. | 54-36-4 |
| 别名 | 美替拉酮; Su-4885 |
| 化学名 | 2-methyl-1,2-di(pyridin-3-yl)propan-1-one |
| Canonical SMILES | O=C(C1=CC=CN=C1)C(C)(C)C2=CC=CN=C2 |
| 分子式 | C14H14N2O |
| 分子量 | 226.27 |
| 溶解度 | ≥ 13.45mg/mL in Water |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Metyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.Target: CYP11B1Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). Metyrapone blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-Deoxycortisol levels. |
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