| CAS NO: | 1370046-40-4 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 1370046-40-4 |
| Canonical SMILES | COC1=C(OC)C(OC)=CC(C2N(C(N)=S)N=C(C3=CC=CC=C3)C2)=C1 |
| 分子式 | C19H21N3O3S |
| 分子量 | 371.45 |
| 溶解度 | DMSO : 150 mg/mL (403.82 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SSE15206 is a microtubule polymerization inhibitor, with a GI50 of 197 nM in a SRB proliferation assay in HCT116 cells. Treatment of cells with SSE15206 result in rounding up of cells which prompt us to look for induction of mitotic arrest using phosphorylation of histone H3 (S10) and MPM2 as mitotic markers. Similarly, treatment with SSE15206 for 8 and 24 hours increase mitotic index compared to the DMSO control. The increase in the mitotic index is quantified and found to be statistically significant at both concentrations and time points. Activation of mitotic kinases, Aurora A, Aurora B and MPS1 in A549 cells accompanied mitotic arrest following SSE15206 treatment. Treatment with 1.25 μM and 2.5 μM concentrations of SSE15206 result in the failure of microtubules to repolymerize at 37 °C following incubation on ice, similar to the positive control nocodazole[1]. [1]. Manzoor S, et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8(1):3305. |
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