D-erythro-MAPP (D-e-MAPP) 是一种神经酰胺酶抑制剂，在体外的 IC50 为 1-5 μM。
| Cas No. | 143492-38-0 |
| 别名 | D-e-MAPP |
| Canonical SMILES | O[C@H]([C@H](N(C(CCCCCCCCCCCCC)=O)[H])C)C1=CC=CC=C1 |
| 分子式 | C23H39NO2 |
| 分子量 | 361.6 |
| 溶解度 | DMF: 20 mg/ml,DMSO: .1 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2) (1:2): .5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | D-erythro-MAPP is a derivative of ceramide and an inhibitor of alkaline ceramidase (Ki = 2-13 µM; IC50 = 1-5 µM). It is selective for alkaline ceramidase over acid ceramidase (IC50 = >500 µM) as well as the serine/threonine protein phosphatase CAPP at concentrations up to 10 µM. D-erythro-MAPP increases intracellular ceramide levels, induces cell cycle arrest at the G0/G1 phase, and inhibits growth of HL-60 promyelocytic leukemia cells in a time- and concentration-dependent manner. |
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