TAN 1364B 是 RK-682 的消旋体，是一种蛋白质酪氨酸磷酸酶 (PTPases) 抑制剂。 TAN 1364B 抑制蛋白酪氨酸磷酸酶 1B (PTP-1B)、低分子量蛋白酪氨酸磷酸酶 (LMW-PTP) 和细胞分裂周期 25B (CDC-25B)，IC50 为 8.6 μM, 12.4 μM 和 0.7 μM，分别。
| Cas No. | 154639-24-4 |
| Canonical SMILES | O=C1C(C(CCCCCCCCCCCCCCC)=O)=C(O)C(CO)O1 |
| 分子式 | C21H36O5 |
| 分子量 | 368.5 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC50s = 8.6, 12.4, and 0.7 µM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces. |
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