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Cotrimoxazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cotrimoxazole图片
CAS NO:8064-90-2
包装与价格:
包装价格(元)
250mg电议
500mg电议
1 g电议
5 g电议

产品介绍
A mixture of the antibiotics sulfamethoxazole and trimethoprom
Cas No.8064-90-2
Canonical SMILESCOC1=C(OC)C(OC)=CC(CC2=CN=C(N)N=C2N)=C1.NC3=CC=C(S(NC4=NOC(C)=C4)(=O)=O)C=C3
分子式C14H18N4O3.C10H11N3O3S
分子量543.6
溶解度DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL,Ethanol: 0.3mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cotrimoxazole is a mixture of the antibiotics sulfamethoxazole and trimethoprim .1,2It is bactericidal against 12 patient-derived community-acquired methicillin-resistantS. aureus(MRSA) strains when used at a concentration of 0.05 mg/L.2Cotrimoxazole (240 mg/kg) prevents lung and spleen bacterial colonization in a mouse model of inhaledB. malleiinfection, but does not eradicate infection when administered postB. malleiexposure in the same model.3It also resolves cutaneous tail lesions in a mouse model ofS. xylosusinfection.4Formulations containing cotrimoxazole have been used in the treatment of MRSA infections and the prevention of glanders disease in human and veterinary medicine, respectively.

1.Lewis, E.L., Anderson, J.D., and Lacey, R.W.A reappraisal of the antibacterial action of cotrimoxazole in vitroJ. Clin. Pathol.27(2)87-91(1974) 2.Kaka, A.S., Rueda, A.M., Shelburne, S.A., III, et al.Bactericidal activity of orally available agents against methicillin-resistant Staphylococcus aureusJ. Antimicrob. Chemother.58(3)680-683(2006) 3.Barnes, K.B., Steward, J., Thwaite, J.E., et al.Trimethoprim/sulfamethoxazole (co-trimoxazole) prophylaxis is effective against acute murine inhalational melioidosis and glandersInt. J. Antimicrob. Agents41(6)552-557(2013) 4.Thornton, V.B., Davis, J.A., St. Clair, M.B., et al.Inoculation of Staphylococcus xylosus in SJL/J mice to determine pathogenicityContemp. Top. Lab. Anim. Sci.42(4)49-52(2003)