| CAS NO: | 1189966-73-1 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1189966-73-1 |
| 别名 | 2-氨基-1,9-[[2-羟基-1-(羟甲基)乙氧基]甲基]-6H,BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5 |
| Canonical SMILES | O=C(N=C(N)N1)C2=C1N(C=N2)COC(C([2H])([2H])O)([2H])C([2H])([2H])O |
| 分子式 | C9H8D5N5O4 |
| 分子量 | 260.3 |
| 溶解度 | DMSO: 0.33 mg/ml |
| 储存条件 | Store at 2°C to 8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ganciclovir-d5is intended for use as an internal standard for the quantification of ganciclovir by GC- or LC-MS. Ganciclovir is a synthetic analog of 2'-deoxy-guanosine that inhibits the replication of human cytomegalovirus (CMV) with an IC50value of 0.01 μM.1,2It is effective against strains of CMV from human, monkey, mouse, and guinea pig.1,2Formulations containing ganciclovir have been used to treat or prevent CMV infections.3,4 1.Rasmussen, L., Chen, P.T., Mullenax, J.G., et al.Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferonsAntimicrob. Agents Chemother.26(4)441-445(1984) 2.Freitas, V.R., Smee, D.F., Chernow, M., et al.Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesAntimicrob. Agents Chemother.28(2)240-245(1985) 3.Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev.Infect.Dis.12(Suppl. 7)S849-S860(1990) 4.Bean, B.Antiviral therapy: Current concepts and practicesClin.Microbiol.Rev.5(2)146-182(1992) |
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