| CAS NO: | 185897-02-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 185897-02-3 |
| 别名 | 茚地那韦-D6,MK-639-d6 free base; L-735524-d6 free base |
| Canonical SMILES | CC(C)(NC([C@H](C1)N(C[C@H](C[C@H](C(N[C@H]2C3=C(C[C@H]2O)C=CC=C3)=O)CC4=CC=CC=C4)O)CCN1C([2H])([2H])C5=C([2H])N=C([2H])C([2H])=C5[2H])=O)C |
| 分子式 | C36H41D6N5O4 |
| 分子量 | 619.8 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Indinavir-d6is intended for use as an internal standard for the quantification of indinavir by GC- or LC-MS. Indinavir is an HIV-1 protease inhibitor (Ki= 0.358 nM).1It is selective for HIV-1 protease over HIV-2 protease (Ki= 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively).2Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM).1Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection. 1.Vacca, J.P., Dorsey, B.D., Schleif, W.A., et al.L-735,524: An orally bioavailable human immunodeficiency virus type 1 protease inhibitorProc. Natl. Acad. Sci. U.S.A.91(9)4096-4100(1994) 2.Dorsey, B.D., McDonough, C., McDaniel, S.L., et al.Identification of MK-944a: A second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitorsJ. Med. Chem.43(18)3386-3399(2000) |
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