| CAS NO: | 1458674-25-3 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1458674-25-3 |
| Canonical SMILES | O=C(C1=CN(C2CC2)C3=CC(N4CCN(CC4)C(NC5=CC=C(C(F)(F)F)C=C5)=S)=C(C=C3C1=O)F)OO=C(C1=CN(C2CC2)C3=CC(N4CCN(CC4)C(NC5=CC=C(C(F)(F)F)C=C5)=S)=C(C=C3C1=O)F)O |
| 分子式 | C25H22F4N4O3S |
| 分子量 | 534.5 |
| 溶解度 | DMF: slightly soluble,DMSO: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active againstE. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively). 1.Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al.Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureusBioorg. Med. Chem.27(20)114962(2019) |
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