| CAS NO: | 1416992-39-6 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| Cas No. | 1416992-39-6 |
| Canonical SMILES | OC([C@H](CC1C(NCC1)=O)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)S([O-])(=O)=O.[Na+] |
| 分子式 | C21H30N3O8S•Na |
| 分子量 | 507.5 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GC376 is an inhibitor of 3C- and 3C-like proteases.1It inhibits recombinant poliovirus, foot and mouth disease virus (FMDV), and human rhinovirus (HRV) 3C proteases (IC50s = 1.77, 1.16, and 0.2 µM, respectively). GC376 also inhibits recombinant Norwalk virus, MD145 virus, transmissible gastroenteritis virus (TGEV), and severe acute respiratory syndrome coronavirus (SARS-CoV) 3C-like proteases (IC50s = 0.49, 0.96, 0.82 and 4.35 µM, respectively). It reduces the cytopathic effect of SARS-CoV-2 in infected Vero E6 cells (EC50= 3.37 µM).2GC376 also reduces liver viral titers by 9.86- and 21.99-fold in a model of murine hepatitis virus (MHV A59) infection when administered at doses of 50 and 100 mg/kg per day, respectively.3 1.Kim, Y., Lovell, S., Tiew, K.-C., et al.Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronavirusesJ. Virol.86(21)11754-11762(2012) 2.Ma, C., Sacco, M.D., Hurst, B., et al.Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main proteaseCell Res.30(8)678-692(2020) 3.Kim, Y., Shivanna, V., Narayanan, S., et al.Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline calicivirusesJ. Virol.89(9)4942-4950(2015) |
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