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CA-4948
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CA-4948图片
CAS NO:1801343-74-7
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
CA-4948 是一种选择性、有效且具有口服活性的白细胞介素-1 受体相关激酶 4 (IRAK4) 抑制剂，提取自专利 WO2015104688（实施例 1）。
Cas No.1801343-74-7
Canonical SMILESO=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3
分子式C21H19N7O3
分子量417.42
溶解度DMSO : 13.89 mg/mL (33.28 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CA-4948 is a selective and potent IRAK4 inhibitor.

CA-4948 is a selective and potent IRAK4 inhibitor which can be used as a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling. CA-4948 exhibits favorable DMPK properties, oral bioavailability, and is well tolerated in mice. Furthermore, CA-4948 is previously shown to exhibit dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models[1].

[1]. Robert N. Booher, et al. Abstract 1168: Efficacy of the IRAK4 inhibitor CA-4948 in patient-derived xenograft models of diffuse large B cell lymphoma. AACR Annual Meeting 2017; April 1-5, 2017;