| CAS NO: | 2044276-16-4 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 2044276-16-4 |
| Canonical SMILES | C[C@H](CCC(NCC(O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C |
| 分子式 | C26H39D4NO4 |
| 分子量 | 437.7 |
| 溶解度 | Chloroform: slightly, heated,Methanol: slightly, heated |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Glycolithocholic acid-d4is intended for use as an internal standard for the quantification of glycolithocholic acid by GC- or LC-MS. Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid .1It is increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid .2Glycolithocholic acid levels are decreased in the plasma following subcutaneous administration of PEG-obestatin(Cys10, Cys13), a modified peptide hormone, in lean or diet-induced obese mice.3Serum glycolithocholic acid levels increase with age in children.4 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Zhang, Y., and Klaassen, C.D.Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in miceJ. Lipid Res.51(11)3230-3242(2010) 3.Cowan, E., Kimar, P., Burch, K.J., et al.Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomicsMetabolomics12(124)(2016) 4.Semba, R.D., Gonzalez-Freier, M., Moaddel, R., et al.Environmental enteric dysfunction is associated with altered bile acid metabolismJ. Pediatr. Gastenterol. Nutr.64(4)536-540(2017) |
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