| CAS NO: | 1398065-69-4 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1398065-69-4 |
| 别名 | 罗氟司特 d4 |
| Canonical SMILES | FC(F)OC1=C(OCC2C([2H])([2H])C2([2H])[2H])C=C(C(NC3=C(Cl)C=NC=C3Cl)=O)C=C1 |
| 分子式 | C17H10Cl2D4F2N2O3 |
| 分子量 | 407.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Roflumilast-d4is intended for use as an internal standard for the quantification of roflumilast by GC- or LC-MS. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50=<1 nm for both human pde4b and pde4d).1It is selective for PDE4, with IC50values against other PDE forms being greater than 10 μM. 1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004) |
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