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sabutoclax(BI 97C1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
sabutoclax(BI 97C1)图片
CAS NO:1228108-65-3
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)700.78
FormulaC42H40N2O8
CAS No.1228108-65-3
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (142.7 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: 54 mg/mL (77 mM)
SynonymsBI-97C1; BI 97C1; BI97C1
实验参考方法
GeneralBI-97C1 displays in vivo efficacy in transgenic mice in which Bcl-2 is overexpressed in splenic B-cells and also demonstrates superior single-agent antitumor efficacy in a prostate cancer mouse xenograft model that depends on Mcl-1 for survival
Animal modelBcl-2 transgenic mice, human prostate cancer xenografts
FormulationEthanol:Cremophor EL:saline = 10:10:80
Dosages1 , 3, 5 mg/kg
Administrationintraperitoneally
Reference[1] Wei J, et al. J Med Chem, 2010, 53(10), 4166-4176
生物活性

The combination regimen of Sabutoclax and Celecoxib inhibits OSCC tumor growth in athymic nude mice. Oncotarget 6(18):16623-37, 2015

Genetic or pharmacological knockdown of Mcl-1 sensitizes PC to mda-7/IL-24–mediated apoptosis. PNAS, 108 (21), 8785–8790, 2011