| CAS NO: | 88039-46-7 |
| 包装: | 10mg |
| 市场价: | 3058元 |
| Cas No. | 88039-46-7 |
| Canonical SMILES | CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O |
| 分子式 | C12H13ClO3 |
| 分子量 | 240.68 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 μM for caspase-1). Inhibits Nigericin or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway. Cocco et al (2014) Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 57 10366 PMID:25418070 |
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