| CAS NO: | 1638644-62-8 |
| 包装: | 10mg |
| 市场价: | 3014元 |
| Cas No. | 1638644-62-8 |
| Canonical SMILES | ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl |
| 分子式 | C16H15ClN4O2.HCl |
| 分子量 | 367.23 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model. Tigno-Aranjuez et al (2014) In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 289 29651 PMID:25213858 |SÁnchez-Duffhues et al (2019) Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 3 e10230 PMID:31768489 |
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