您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Mycophenolate Mofetil-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Mycophenolate Mofetil-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mycophenolate Mofetil-d4图片
CAS NO:1132748-21-0
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
吗替麦考酚酯-d4 是氘标记的吗替麦考酚酯。 Mycophenolate mofetil (RS 61443) 是霉酚酸的吗啉代乙酯前药。 Mycophenolate mofetil 通过抑制肌苷一磷酸脱氢酶 (IMPDH) 来抑制从头嘌呤合成。 Mycophenolate mofetil 显示选择性淋巴细胞抗增殖作用涉及 T 细胞和 B 细胞,防止抗体形成。
Cas No.1132748-21-0
别名吗替麦考酚酯 d4
Canonical SMILESO=C(OC1)C2=C1C(C)=C(OC)C(C/C=C(C)/CCC(OC([2H])([2H])C([2H])([2H])N3CCOCC3)=O)=C2O
分子式C23H27D4NO7
分子量437.5
溶解度DMF: 14 mg/ml,DMSO: 10 mg/ml,Ethanol: 1.4 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mycophenolate mofetil-d4is intended for use as an internal standard for the quantification of mycophenolate mofetil by GC- or LC-MS. Mycophenolate mofetil is a prodrug form of mycophenolic acid .1,2,3In vivo, mycophenolate mofetil (12.5 mg/kg) increases duration of transplant motor activity in a rabbit model of retroperitoneal heterotopic heart transplantation.1It eliminates formation of microbleeds and hemorrhages in the cerebrum of stroke-prone spontaneously hypertensive rats.2Mycophenolate mofetil also lowers mean arterial pressure (MAP) and reduces urinary albumin excretion and glomerulosclerosis, markers of renal damage, in a mouse model of systemic lupus erythematosus (SLE).3

1.AygÜn, F., Efe, D., and Durgut, K.Comparison of MMF with prednisone in terms of rejection and duration of activity of transplant in rabbits that underwent retroperitoneal heterotopic heart transplantationCardiovasc. J. Afr.26(3)104-108(2015) 2.Dhande, I.S., Zhu, Y., Braun, M.C., et al.Mycophenolate mofetil prevents cerebrovascular injury in stroke-prone spontaneously hypertensive ratsPhysiol. Genomics49(3)132-140(2017) 3.Taylor, E.B., and Ryan, M.J.Immunosuppression with mycophenolate mofetil attenuates hypertension in an experimental model of autoimmune diseaseJ. Am. Heart Assoc.6(3)e005394(2017)